Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae.

Journal Article (Journal Article)

In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.

Full Text

Duke Authors

Cited Authors

  • Fan, QQ; Xu, F; White, MA; Petes, TD

Published Date

  • March 1997

Published In

Volume / Issue

  • 145 / 3

Start / End Page

  • 661 - 670

PubMed ID

  • 9055076

Pubmed Central ID

  • PMC1207851

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1093/genetics/145.3.661


  • eng

Conference Location

  • United States