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Microsatellite instability in yeast: dependence on the length of the microsatellite.

Publication ,  Journal Article
Wierdl, M; Dominska, M; Petes, TD
Published in: Genetics
July 1997

One of the most common microsatellites in eukaryotes consists of tandem arrays [usually 15-50 base pairs (bp) in length] of the dinucleotide GT. We examined the rates of instability for poly GT tracts of 15, 33, 51, 99 and 105 bp in wild-type and mismatch repair-deficient strains of Saccharomyces cerevisiae. Rates of instability increased more than two orders of magnitude as tracts increased in size from 15 to 99 bp in both wild-type and msh2 strains. The types of alterations observed in long and short tracts in wild-type strains were different in two ways. First, tracts > or = 51 bp had significantly more large deletions than tracts < or = 33 bp. Second, for the 99- and 105-bp tracts, almost all events involving single repeats were additions; for the smaller tracts, both additions and deletions of single repeats were common.

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Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

July 1997

Volume

146

Issue

3

Start / End Page

769 / 779

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Microsatellite Repeats
  • Dinucleotide Repeats
  • Developmental Biology
  • DNA, Fungal
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics
 

Citation

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Wierdl, M., Dominska, M., & Petes, T. D. (1997). Microsatellite instability in yeast: dependence on the length of the microsatellite. Genetics, 146(3), 769–779. https://doi.org/10.1093/genetics/146.3.769
Wierdl, M., M. Dominska, and T. D. Petes. “Microsatellite instability in yeast: dependence on the length of the microsatellite.Genetics 146, no. 3 (July 1997): 769–79. https://doi.org/10.1093/genetics/146.3.769.
Wierdl M, Dominska M, Petes TD. Microsatellite instability in yeast: dependence on the length of the microsatellite. Genetics. 1997 Jul;146(3):769–79.
Wierdl, M., et al. “Microsatellite instability in yeast: dependence on the length of the microsatellite.Genetics, vol. 146, no. 3, July 1997, pp. 769–79. Pubmed, doi:10.1093/genetics/146.3.769.
Wierdl M, Dominska M, Petes TD. Microsatellite instability in yeast: dependence on the length of the microsatellite. Genetics. 1997 Jul;146(3):769–779.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

July 1997

Volume

146

Issue

3

Start / End Page

769 / 779

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae
  • Recombination, Genetic
  • Microsatellite Repeats
  • Dinucleotide Repeats
  • Developmental Biology
  • DNA, Fungal
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics