Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins.
Journal Article (Journal Article)
A number of enzymes recognize and repair DNA lesions. The DNA-mismatch repair system corrects base-base mismatches and small loops, whereas the nucleotide-excision repair system removes pyrimidine dimers and other helix-distorting lesions. DNA molecules with mismatches or loops can arise as a consequence of heteroduplex formation during meiotic recombination. In the yeast Saccharomyces cerevisiae, repair of mismatches results in gene conversion or restoration, and failure to repair the mismatch results in post-meiotic segregation (PMS). The ratio of gene-conversion to PMS events reflects the efficiency of DNA repair. By examining the PMS patterns in yeast strains heterozygous for a mutant allele with a 26-base-pair insertion, we find that the repair of 26-base loops involves Msh2 (a DNA-mismatch repair protein) and Rad1 (a protein required for nucleotide-excision repair).
Full Text
Duke Authors
Cited Authors
- Kirkpatrick, DT; Petes, TD
Published Date
- June 26, 1997
Published In
Volume / Issue
- 387 / 6636
Start / End Page
- 929 - 931
PubMed ID
- 9202128
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/43225
Language
- eng
Conference Location
- England