Destabilization of simple repetitive DNA sequences by transcription in yeast.
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
Wierdl, M; Greene, CN; Datta, A; Jinks-Robertson, S; Petes, TD
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