Destabilization of simple repetitive DNA sequences by transcription in yeast.

Journal Article (Journal Article)

Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.

Full Text

Duke Authors

Cited Authors

  • Wierdl, M; Greene, CN; Datta, A; Jinks-Robertson, S; Petes, TD

Published Date

  • June 1996

Published In

Volume / Issue

  • 143 / 2

Start / End Page

  • 713 - 721

PubMed ID

  • 8725221

Pubmed Central ID

  • PMC1207331

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1093/genetics/143.2.713


  • eng

Conference Location

  • United States