Destabilization of simple repetitive DNA sequences by transcription in yeast.
Journal Article (Journal Article)
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
- Wierdl, M; Greene, CN; Datta, A; Jinks-Robertson, S; Petes, TD
- June 1996
Volume / Issue
- 143 / 2
Start / End Page
- 713 - 721
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States