Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
Publication
, Journal Article
Fan, QQ; Petes, TD
Published in: Mol Cell Biol
May 1996
Meiotic double-strand DNA breaks (DSBs), the lesions that initiate meiotic recombination at the HIS4 recombination hot spot, occur in a region upstream of the coding sequence associated with multiple DNase I-hypersensitive sites. Mutations in transcription factors that lead to loss of the DSBs result in the loss of some but not all DNase I-hypersensitive sites in the upstream region. A meiosis-specific change in chromatin structure is detected in strains with the wild-type hot spot but not in strains with alterations that elevate or reduce hot spot activity. The position and intensity of micrococcal nuclease-hypersensitive sites correlate poorly with the sites of DSB formation.
Duke Scholars
Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
May 1996
Volume
16
Issue
5
Start / End Page
2037 / 2043
Location
United States
Related Subject Headings
- Transcription Factors
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Restriction Mapping
- Recombination, Genetic
- Pyrophosphatases
- Promoter Regions, Genetic
- Multienzyme Complexes
- Mitosis
- Meiosis
Citation
APA
Chicago
ICMJE
MLA
NLM
Fan, Q. Q., & Petes, T. D. (1996). Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae. Mol Cell Biol, 16(5), 2037–2043. https://doi.org/10.1128/MCB.16.5.2037
Fan, Q. Q., and T. D. Petes. “Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.” Mol Cell Biol 16, no. 5 (May 1996): 2037–43. https://doi.org/10.1128/MCB.16.5.2037.
Fan QQ, Petes TD. Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae. Mol Cell Biol. 1996 May;16(5):2037–43.
Fan, Q. Q., and T. D. Petes. “Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.” Mol Cell Biol, vol. 16, no. 5, May 1996, pp. 2037–43. Pubmed, doi:10.1128/MCB.16.5.2037.
Fan QQ, Petes TD. Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae. Mol Cell Biol. 1996 May;16(5):2037–2043.
Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
May 1996
Volume
16
Issue
5
Start / End Page
2037 / 2043
Location
United States
Related Subject Headings
- Transcription Factors
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Restriction Mapping
- Recombination, Genetic
- Pyrophosphatases
- Promoter Regions, Genetic
- Multienzyme Complexes
- Mitosis
- Meiosis