TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

Journal Article

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

Full Text

Duke Authors

Cited Authors

  • Greenwell, PW; Kronmal, SL; Porter, SE; Gassenhuber, J; Obermaier, B; Petes, TD

Published Date

  • September 8, 1995

Published In

Volume / Issue

  • 82 / 5

Start / End Page

  • 823 - 829

PubMed ID

  • 7671310

International Standard Serial Number (ISSN)

  • 0092-8674

Language

  • eng

Conference Location

  • United States