Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.
Publication
, Journal Article
Fan, Q; Xu, F; Petes, TD
Published in: Mol Cell Biol
March 1995
The region of Saccharomyces cerevisiae chromosome III located between the 5' end of the HIS4 gene and the 3' end of the adjacent BIK1 gene has a very high level of meiotic recombination. In wild-type strains, a meiosis-specific double-strand DNA break occurs in the hot spot region. This break is absent in strains in which the transcription factors Rap1p, Bas1p, and Bas2p cannot bind to the region upstream of HIS4. In strains with levels of recombination that are higher than those of the wild type, the break is found at elevated levels. The linear relationship between hot spot activity and the frequency of double-strand DNA breaks suggests that these lesions are responsible for initiating recombination at the HIS4 recombination hot spot.
Duke Scholars
Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
March 1995
Volume
15
Issue
3
Start / End Page
1679 / 1688
Location
United States
Related Subject Headings
- Transcription Factors
- Species Specificity
- Saccharomyces cerevisiae
- Regulatory Sequences, Nucleic Acid
- Recombination, Genetic
- Plasmids
- Meiosis
- Haploidy
- Genotype
- Developmental Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Fan, Q., Xu, F., & Petes, T. D. (1995). Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. Mol Cell Biol, 15(3), 1679–1688. https://doi.org/10.1128/MCB.15.3.1679
Fan, Q., F. Xu, and T. D. Petes. “Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.” Mol Cell Biol 15, no. 3 (March 1995): 1679–88. https://doi.org/10.1128/MCB.15.3.1679.
Fan Q, Xu F, Petes TD. Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. Mol Cell Biol. 1995 Mar;15(3):1679–88.
Fan, Q., et al. “Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.” Mol Cell Biol, vol. 15, no. 3, Mar. 1995, pp. 1679–88. Pubmed, doi:10.1128/MCB.15.3.1679.
Fan Q, Xu F, Petes TD. Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. Mol Cell Biol. 1995 Mar;15(3):1679–1688.
Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
March 1995
Volume
15
Issue
3
Start / End Page
1679 / 1688
Location
United States
Related Subject Headings
- Transcription Factors
- Species Specificity
- Saccharomyces cerevisiae
- Regulatory Sequences, Nucleic Acid
- Recombination, Genetic
- Plasmids
- Meiosis
- Haploidy
- Genotype
- Developmental Biology