Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break.
Publication
, Journal Article
Porter, SE; White, MA; Petes, TD
Published in: Genetics
May 1993
In the yeast Saccharomyces cerevisiae, the binding of the Rap1 protein to a site located between the 5' end of the HIS4 gene and the 3' end of BIK1 stimulates meiotic recombination at both flanking loci. By using strains that contain mutations located in HIS4 and BIK1, we found that most recombination events stimulated by the binding of Rap1 involve HIS4 or BIK1, rather than bidirectional events including both loci. The patterns of aberrant segregation indicate that most of the Rap1-stimulated recombination events do not represent the symmetric processing of a double-strand DNA break located at the Rap1-binding site.
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Published In
Genetics
DOI
ISSN
0016-6731
Publication Date
May 1993
Volume
134
Issue
1
Start / End Page
5 / 19
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Saccharomyces cerevisiae
- Recombination, Genetic
- Nucleic Acid Heteroduplexes
- Mutation
- Molecular Sequence Data
- Meiosis
- Genes, Fungal
- GTP-Binding Proteins
- Fungal Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Porter, S. E., White, M. A., & Petes, T. D. (1993). Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. Genetics, 134(1), 5–19. https://doi.org/10.1093/genetics/134.1.5
Porter, S. E., M. A. White, and T. D. Petes. “Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break.” Genetics 134, no. 1 (May 1993): 5–19. https://doi.org/10.1093/genetics/134.1.5.
Porter SE, White MA, Petes TD. Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. Genetics. 1993 May;134(1):5–19.
Porter, S. E., et al. “Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break.” Genetics, vol. 134, no. 1, May 1993, pp. 5–19. Pubmed, doi:10.1093/genetics/134.1.5.
Porter SE, White MA, Petes TD. Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. Genetics. 1993 May;134(1):5–19.
Published In
Genetics
DOI
ISSN
0016-6731
Publication Date
May 1993
Volume
134
Issue
1
Start / End Page
5 / 19
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Saccharomyces cerevisiae
- Recombination, Genetic
- Nucleic Acid Heteroduplexes
- Mutation
- Molecular Sequence Data
- Meiosis
- Genes, Fungal
- GTP-Binding Proteins
- Fungal Proteins