Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.

Journal Article (Journal Article)

The full activity of a recombination initiation site located 5' of HIS4 requires the binding of the transcription factors RAP1, BAS1, and BAS2. Two RAP1 binding sites can substitute for the wild-type initiation site. A 51-bp region of telomeric DNA inserted upstream of either HIS4 or ARG4 very strongly stimulates recombination. We suggest that the ability of transcription factors to induce recombination is a consequence of an altered chromatin structure that favors the entry of proteins that initiate recombination, rather than an effect of these factors on transcription.

Full Text

Duke Authors

Cited Authors

  • White, MA; Dominska, M; Petes, TD

Published Date

  • July 15, 1993

Published In

Volume / Issue

  • 90 / 14

Start / End Page

  • 6621 - 6625

PubMed ID

  • 8341678

Pubmed Central ID

  • PMC46984

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.90.14.6621


  • eng

Conference Location

  • United States