Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.
Journal Article (Journal Article)
The full activity of a recombination initiation site located 5' of HIS4 requires the binding of the transcription factors RAP1, BAS1, and BAS2. Two RAP1 binding sites can substitute for the wild-type initiation site. A 51-bp region of telomeric DNA inserted upstream of either HIS4 or ARG4 very strongly stimulates recombination. We suggest that the ability of transcription factors to induce recombination is a consequence of an altered chromatin structure that favors the entry of proteins that initiate recombination, rather than an effect of these factors on transcription.
Full Text
Duke Authors
Cited Authors
- White, MA; Dominska, M; Petes, TD
Published Date
- July 15, 1993
Published In
Volume / Issue
- 90 / 14
Start / End Page
- 6621 - 6625
PubMed ID
- 8341678
Pubmed Central ID
- PMC46984
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.90.14.6621
Language
- eng
Conference Location
- United States