DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.

Journal Article (Journal Article)

In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.

Full Text

Duke Authors

Cited Authors

  • White, MA; Wierdl, M; Detloff, P; Petes, TD

Published Date

  • November 1, 1991

Published In

Volume / Issue

  • 88 / 21

Start / End Page

  • 9755 - 9759

PubMed ID

  • 1946399

Pubmed Central ID

  • PMC52799

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.88.21.9755


  • eng

Conference Location

  • United States