DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.


Journal Article

In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.

Full Text

Duke Authors

Cited Authors

  • White, MA; Wierdl, M; Detloff, P; Petes, TD

Published Date

  • November 1, 1991

Published In

Volume / Issue

  • 88 / 21

Start / End Page

  • 9755 - 9759

PubMed ID

  • 1946399

Pubmed Central ID

  • 1946399

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.88.21.9755


  • eng

Conference Location

  • United States