Genetic analysis of a meiotic recombination hotspot on chromosome III of Saccharomyces cerevisiae.
Journal Article (Journal Article)
In a previous study, we analyzed meiotic recombination events that occurred in the 22-kb region (LEU2 to CEN3) of chromosome III of Saccharomyces cerevisiae. We found one region with an enhanced level of crossovers (a hotspot) and one region with a depressed level of crossovers. In this study, we show that about one-third of the crossovers that occur between LEU2 and CEN3 are initiated in a 1.3-kb region located approximately 6 kb from the centromere. Both crossovers and gene conversion events are initiated at this site. Events initiated at this position can be resolved as crossovers in regions located either centromere-distally or centromere-proximally from the initiation site.
Full Text
Duke Authors
Cited Authors
- Symington, LS; Brown, A; Oliver, SG; Greenwell, P; Petes, TD
Published Date
- August 1991
Published In
Volume / Issue
- 128 / 4
Start / End Page
- 717 - 727
PubMed ID
- 1840557
Pubmed Central ID
- PMC1204546
International Standard Serial Number (ISSN)
- 0016-6731
Digital Object Identifier (DOI)
- 10.1093/genetics/128.4.717
Language
- eng
Conference Location
- United States