Genetic analysis of a meiotic recombination hotspot on chromosome III of Saccharomyces cerevisiae.

Journal Article (Journal Article)

In a previous study, we analyzed meiotic recombination events that occurred in the 22-kb region (LEU2 to CEN3) of chromosome III of Saccharomyces cerevisiae. We found one region with an enhanced level of crossovers (a hotspot) and one region with a depressed level of crossovers. In this study, we show that about one-third of the crossovers that occur between LEU2 and CEN3 are initiated in a 1.3-kb region located approximately 6 kb from the centromere. Both crossovers and gene conversion events are initiated at this site. Events initiated at this position can be resolved as crossovers in regions located either centromere-distally or centromere-proximally from the initiation site.

Full Text

Duke Authors

Cited Authors

  • Symington, LS; Brown, A; Oliver, SG; Greenwell, P; Petes, TD

Published Date

  • August 1991

Published In

Volume / Issue

  • 128 / 4

Start / End Page

  • 717 - 727

PubMed ID

  • 1840557

Pubmed Central ID

  • PMC1204546

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1093/genetics/128.4.717


  • eng

Conference Location

  • United States