Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III.
Journal Article (Journal Article)
To examine the relationship between genetic and physical chromosome maps, we constructed a diploid strain of the yeast Saccharomyces cerevisiae heterozygous for 12 restriction site mutations within a 23-kilobase (5-centimorgan) interval of chromosome III. Crossovers were not uniformly distributed along the chromosome, one interval containing significantly more and one interval significantly fewer crossovers than expected. One-third of these crossovers occurred within 6 kilobases of the centromere. Approximately half of the exchanges were associated with gene conversion events. The minimum length of gene conversion tracts varied from 4 base pairs to more than 12 kilobases, and these tracts were nonuniformly distributed along the chromosome. We conclude that the chromosomal sequence or structure has a dramatic effect on meiotic recombination.
Full Text
Duke Authors
Cited Authors
- Symington, LS; Petes, TD
Published Date
- February 1, 1988
Published In
Volume / Issue
- 8 / 2
Start / End Page
- 595 - 604
PubMed ID
- 2832729
Pubmed Central ID
- PMC363185
International Standard Serial Number (ISSN)
- 0270-7306
Digital Object Identifier (DOI)
- 10.1128/mcb.8.2.595-604.1988
Language
- eng
Conference Location
- United States