Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III.


Journal Article

To examine the relationship between genetic and physical chromosome maps, we constructed a diploid strain of the yeast Saccharomyces cerevisiae heterozygous for 12 restriction site mutations within a 23-kilobase (5-centimorgan) interval of chromosome III. Crossovers were not uniformly distributed along the chromosome, one interval containing significantly more and one interval significantly fewer crossovers than expected. One-third of these crossovers occurred within 6 kilobases of the centromere. Approximately half of the exchanges were associated with gene conversion events. The minimum length of gene conversion tracts varied from 4 base pairs to more than 12 kilobases, and these tracts were nonuniformly distributed along the chromosome. We conclude that the chromosomal sequence or structure has a dramatic effect on meiotic recombination.

Full Text

Duke Authors

Cited Authors

  • Symington, LS; Petes, TD

Published Date

  • February 1, 1988

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 595 - 604

PubMed ID

  • 2832729

Pubmed Central ID

  • 2832729

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.8.2.595


  • eng

Conference Location

  • United States