Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III.

Journal Article (Journal Article)

To examine the relationship between genetic and physical chromosome maps, we constructed a diploid strain of the yeast Saccharomyces cerevisiae heterozygous for 12 restriction site mutations within a 23-kilobase (5-centimorgan) interval of chromosome III. Crossovers were not uniformly distributed along the chromosome, one interval containing significantly more and one interval significantly fewer crossovers than expected. One-third of these crossovers occurred within 6 kilobases of the centromere. Approximately half of the exchanges were associated with gene conversion events. The minimum length of gene conversion tracts varied from 4 base pairs to more than 12 kilobases, and these tracts were nonuniformly distributed along the chromosome. We conclude that the chromosomal sequence or structure has a dramatic effect on meiotic recombination.

Full Text

Duke Authors

Cited Authors

  • Symington, LS; Petes, TD

Published Date

  • February 1, 1988

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 595 - 604

PubMed ID

  • 2832729

Pubmed Central ID

  • PMC363185

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.8.2.595-604.1988


  • eng

Conference Location

  • United States