Vulnerable plaque intervention: State of the art.

Journal Article (Journal Article;Review)

Progressive atherosclerotic disease is responsible for many of the late adverse clinical events that detract from the high procedural and clinical success of percutaneous coronary intervention. Despite recent advances in catheter based technology for the treatment of obstructive coronary artery disease, the greater risk to the patient over time may in fact come from the significant rate of acute coronary events triggered by nonculprit and/or nonobstructive coronary artery lesions. These areas of vulnerability within the epicardial coronary tree have generated a great deal of interest surrounding the concepts of vulnerable plaque (VP), vulnerable blood and the vulnerable patient. This 'state of the art' review discusses the limitations of coronary angiography alone in providing risk assessment; reviews the underlying biological concepts of VP; discusses evolving noninvasive and invasive imaging technologies for the detection of VP; and finally provides a futuristic look at how the field of interventional cardiology may transcend the traditional angiogram and move toward a more comprehensive treatment approach that benefits the patients' overall coronary health.

Full Text

Duke Authors

Cited Authors

  • Young, JJ; Phillips, HR; Marso, SP; Granada, JF; McPherson, JA; Waksman, R; Steinhubl, SR; Schwartz, RS; Stone, GW

Published Date

  • February 15, 2008

Published In

Volume / Issue

  • 71 / 3

Start / End Page

  • 367 - 374

PubMed ID

  • 18288729

Electronic International Standard Serial Number (EISSN)

  • 1522-726X

Digital Object Identifier (DOI)

  • 10.1002/ccd.21354


  • eng

Conference Location

  • United States