Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.

Journal Article (Journal Article)

We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.

Full Text

Duke Authors

Cited Authors

  • Santos, RM; Tanguay, JF; Crowley, JJ; Kruse, KR; Sanders-Millare, D; Zidar, JP; Phillips, HR; Merhi, Y; Garcia-Cantu, E; Bonan, R; Côté, G; Stack, RS

Published Date

  • September 1, 1998

Published In

Volume / Issue

  • 82 / 5

Start / End Page

  • 673 - A8

PubMed ID

  • 9732901

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/s0002-9149(98)00418-4


  • eng

Conference Location

  • United States