Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy.
Journal Article (Journal Article)
A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.
Full Text
Duke Authors
Cited Authors
- Fedor, JM; Stack, RS; Pryor, DB; Phillips, HR
Published Date
- April 1, 1983
Published In
Volume / Issue
- 83 / 4
Start / End Page
- 704 - 706
PubMed ID
- 6682029
Pubmed Central ID
- 6682029
International Standard Serial Number (ISSN)
- 0012-3692
Digital Object Identifier (DOI)
- 10.1378/chest.83.4.704
Language
- eng
Conference Location
- United States