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Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning.

Publication ,  Journal Article
Hampson, NB; Simonson, SG; Kramer, CC; Piantadosi, CA
Published in: Undersea Hyperb Med
December 1996

Hyperbaric oxygen (HBO2) is associated with a recognized risk for clinical central nervous system (CNS) toxicity. The risk for oxygen convulsions during routine hyperbaric treatment of most routine conditions is extremely low. Previous observations have suggested that the incidence of CNS toxicity during HBO2 treatment for carbon monoxide (CO) poisoning may be increased, both because of CNS injury caused by the poisoning and because higher treatment pressures are often utilized for this condition. This study reviews data from 900 CO-poisoned patients treated with HBO2 at Virginia Mason and Duke University Medical Centers from 1987 to 1996. One-third of the patient population was treated at each of the three HBO2 treatment pressures most commonly utilized for CO intoxication in North American multiplace chambers. Patient characteristics were similar in all groups. Among the 300 consecutive patients treated at each pressure, there was one seizure at 2.45 atm abs (0.3%), nine seizures at 2.80 atm abs (2.0%), and six seizures at 3.00 atm abs. This difference is statistically significant (P = 0.032; Fisher's Exact Test). The potential difference in seizure risk should be considered when selecting the HBO2 treatment pressure for CO poisoning.

Duke Scholars

Published In

Undersea Hyperb Med

ISSN

1066-2936

Publication Date

December 1996

Volume

23

Issue

4

Start / End Page

215 / 219

Location

United States

Related Subject Headings

  • Seizures
  • Pressure
  • Physiology
  • Male
  • Hyperbaric Oxygenation
  • Humans
  • Female
  • Carbon Monoxide Poisoning
  • Adult
  • 3202 Clinical sciences
 

Citation

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Hampson, N. B., Simonson, S. G., Kramer, C. C., & Piantadosi, C. A. (1996). Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med, 23(4), 215–219.
Hampson, N. B., S. G. Simonson, C. C. Kramer, and C. A. Piantadosi. “Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning.Undersea Hyperb Med 23, no. 4 (December 1996): 215–19.
Hampson NB, Simonson SG, Kramer CC, Piantadosi CA. Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med. 1996 Dec;23(4):215–9.
Hampson, N. B., et al. “Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning.Undersea Hyperb Med, vol. 23, no. 4, Dec. 1996, pp. 215–19.
Hampson NB, Simonson SG, Kramer CC, Piantadosi CA. Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning. Undersea Hyperb Med. 1996 Dec;23(4):215–219.

Published In

Undersea Hyperb Med

ISSN

1066-2936

Publication Date

December 1996

Volume

23

Issue

4

Start / End Page

215 / 219

Location

United States

Related Subject Headings

  • Seizures
  • Pressure
  • Physiology
  • Male
  • Hyperbaric Oxygenation
  • Humans
  • Female
  • Carbon Monoxide Poisoning
  • Adult
  • 3202 Clinical sciences