Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes.

Published online

Journal Article (Review)

Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death can occur and they vary in their capacity to stimulate as well as inhibit inflammation. The pro-inflammatory activity of dead cells results from a wide variety of intracellular molecules that are released as cell permeability increases during death. These molecules have been termed as DAMPs (damage associated molecular patterns) or alarmins. Among these DAMPs, HMGB1, a non-histone nuclear protein, serves as the prototype. Although HMGB1 was originally thought to act alone as a cytokine, recent studies suggest that its immunological effects result from complexes of HMGB1 with either other DAMPs or with PAMPs (pathogen associated molecular patterns). Studies on the role of HMGB1 in pathogenesis suggest that the formation of extracellular complexes is an important mechanism for generating pro-inflammatory signals during cell death and therefore could be a potential target of new therapy.

Full Text

Duke Authors

Cited Authors

  • Pisetsky, D

Published Date

  • 2011

Published In

Volume / Issue

  • 141 /

Start / End Page

  • w13256 -

PubMed ID

  • 21877298

Pubmed Central ID

  • 21877298

Electronic International Standard Serial Number (EISSN)

  • 1424-3997

Digital Object Identifier (DOI)

  • 10.4414/smw.2011.13256

Language

  • eng

Conference Location

  • Switzerland