Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.

Journal Article (Journal Article;Review)

The four fibroblast growth factor homologous factors (FHFs; FGF11-FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs). Although FHFs have been well studied in neurons and implicated in neurologic disease, their role in cardiomyocytes was unclear until recently. This review discusses the expression profile and function of FHFs in mouse and rat ventricular cardiomyocytes. Recent data show that FGF13 is the predominant FHF in the murine heart, directly binds the cardiac VGSC α subunit, and is essential for normal cardiac conduction. FHF loss-of-function mutations may be unrecognized causes of cardiac arrhythmias, such as long QT and Brugada syndromes.

Full Text

Duke Authors

Cited Authors

  • Wei, EQ; Barnett, AS; Pitt, GS; Hennessey, JA

Published Date

  • October 2011

Published In

Volume / Issue

  • 21 / 7

Start / End Page

  • 199 - 203

PubMed ID

  • 22867699

Pubmed Central ID

  • PMC3413878

Electronic International Standard Serial Number (EISSN)

  • 1873-2615

Digital Object Identifier (DOI)

  • 10.1016/j.tcm.2012.05.010


  • eng

Conference Location

  • United States