Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.
Publication
, Journal Article
Wei, EQ; Barnett, AS; Pitt, GS; Hennessey, JA
Published in: Trends Cardiovasc Med
October 2011
The four fibroblast growth factor homologous factors (FHFs; FGF11-FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs). Although FHFs have been well studied in neurons and implicated in neurologic disease, their role in cardiomyocytes was unclear until recently. This review discusses the expression profile and function of FHFs in mouse and rat ventricular cardiomyocytes. Recent data show that FGF13 is the predominant FHF in the murine heart, directly binds the cardiac VGSC α subunit, and is essential for normal cardiac conduction. FHF loss-of-function mutations may be unrecognized causes of cardiac arrhythmias, such as long QT and Brugada syndromes.
Duke Scholars
Published In
Trends Cardiovasc Med
DOI
EISSN
1873-2615
Publication Date
October 2011
Volume
21
Issue
7
Start / End Page
199 / 203
Location
United States
Related Subject Headings
- Voltage-Gated Sodium Channels
- Risk Factors
- Rats
- Myocytes, Cardiac
- Mutation
- Mice
- Heart
- Fibroblast Growth Factors
- Disease Models, Animal
- Cardiovascular System & Hematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Wei, E. Q., Barnett, A. S., Pitt, G. S., & Hennessey, J. A. (2011). Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Trends Cardiovasc Med, 21(7), 199–203. https://doi.org/10.1016/j.tcm.2012.05.010
Wei, Eric Q., Adam S. Barnett, Geoffrey S. Pitt, and Jessica A. Hennessey. “Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.” Trends Cardiovasc Med 21, no. 7 (October 2011): 199–203. https://doi.org/10.1016/j.tcm.2012.05.010.
Wei EQ, Barnett AS, Pitt GS, Hennessey JA. Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Trends Cardiovasc Med. 2011 Oct;21(7):199–203.
Wei, Eric Q., et al. “Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.” Trends Cardiovasc Med, vol. 21, no. 7, Oct. 2011, pp. 199–203. Pubmed, doi:10.1016/j.tcm.2012.05.010.
Wei EQ, Barnett AS, Pitt GS, Hennessey JA. Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Trends Cardiovasc Med. 2011 Oct;21(7):199–203.
Published In
Trends Cardiovasc Med
DOI
EISSN
1873-2615
Publication Date
October 2011
Volume
21
Issue
7
Start / End Page
199 / 203
Location
United States
Related Subject Headings
- Voltage-Gated Sodium Channels
- Risk Factors
- Rats
- Myocytes, Cardiac
- Mutation
- Mice
- Heart
- Fibroblast Growth Factors
- Disease Models, Animal
- Cardiovascular System & Hematology