Posterior cingulate cortex mediates outcome-contingent allocation of behavior.

Published

Journal Article

Adaptive decision making requires selecting an action and then monitoring its consequences to improve future decisions. The neuronal mechanisms supporting action evaluation and subsequent behavioral modification, however, remain poorly understood. To investigate the contribution of posterior cingulate cortex (CGp) to these processes, we recorded activity of single neurons in monkeys performing a gambling task in which the reward outcome of each choice strongly influenced subsequent choices. We found that CGp neurons signaled reward outcomes in a nonlinear fashion and that outcome-contingent modulations in firing rate persisted into subsequent trials. Moreover, firing rate on any one trial predicted switching to the alternative option on the next trial. Finally, microstimulation in CGp following risky choices promoted a preference reversal for the safe option on the following trial. Collectively, these results demonstrate that CGp directly contributes to the evaluative processes that support dynamic changes in decision making in volatile environments.

Full Text

Cited Authors

  • Hayden, BY; Nair, AC; McCoy, AN; Platt, ML

Published Date

  • October 9, 2008

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 19 - 25

PubMed ID

  • 18940585

Pubmed Central ID

  • 18940585

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.09.012

Language

  • eng

Conference Location

  • United States