tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.

Journal Article (Journal Article)

Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.

Full Text

Duke Authors

Cited Authors

  • Kikuchi, K; Gupta, V; Wang, J; Holdway, JE; Wills, AA; Fang, Y; Poss, KD

Published Date

  • July 2011

Published In

Volume / Issue

  • 138 / 14

Start / End Page

  • 2895 - 2902

PubMed ID

  • 21653610

Pubmed Central ID

  • PMC3119303

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.067041


  • eng

Conference Location

  • England