Skip to main content
Journal cover image

Neural correlates associated with cognitive decline in late-life depression.

Publication ,  Journal Article
Wang, L; Potter, GG; Krishnan, RKR; Dolcos, F; Smith, GS; Steffens, DC
Published in: Am J Geriatr Psychiatry
August 2012

OBJECTIVES: Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD. DESIGN: Longitudinal study. SETTING: Outpatient depression treatment study at Duke University. PARTICIPANTS: Twenty-three patients with LLD completed a 2-year follow-up study, and were in a remitted or partially remitted state at Year 2. METHODS: At first entry to the study (Year 0), all participants had a functional magnetic resonance imaging scan while performing an emotional oddball task. For the purpose of this report, the primary functional magnetic resonance imaging outcome was brain activation during target detection, which is a measure of executive function. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery was used to assess cognitive status yearly, and the Montgomery-Åsberg Depression Rating Scale was used to assess severity of depression at Year 0 and every 6 months thereafter for 2 years. We investigated changes in brain activation at Year 0 associated with PCI over 2 years. RESULTS: Patients with PCI at the 2-year follow-up date had significantly decreased activation at Year 0 in the dorsal anterior cingulate cortex, hippocampus, inferior frontal cortex, and insula compared to non-PCI patients. CONCLUSIONS: Our results suggest individuals who have LLD with PCI have decreased activation in the similar neural networks associated with the development of Alzheimer disease among nondepressed individuals. Measuring neural activity in these regions in individuals with LLD may help identify patients at-risk for cognitive impairment.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

August 2012

Volume

20

Issue

8

Start / End Page

653 / 663

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Outpatients
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Depression
  • Cognition Disorders
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, L., Potter, G. G., Krishnan, R. K. R., Dolcos, F., Smith, G. S., & Steffens, D. C. (2012). Neural correlates associated with cognitive decline in late-life depression. Am J Geriatr Psychiatry, 20(8), 653–663. https://doi.org/10.1097/JGP.0b013e31823e2cc7
Wang, Lihong, Guy G. Potter, RK Ranga Krishnan, Florin Dolcos, Gwenn S. Smith, and David C. Steffens. “Neural correlates associated with cognitive decline in late-life depression.Am J Geriatr Psychiatry 20, no. 8 (August 2012): 653–63. https://doi.org/10.1097/JGP.0b013e31823e2cc7.
Wang L, Potter GG, Krishnan RKR, Dolcos F, Smith GS, Steffens DC. Neural correlates associated with cognitive decline in late-life depression. Am J Geriatr Psychiatry. 2012 Aug;20(8):653–63.
Wang, Lihong, et al. “Neural correlates associated with cognitive decline in late-life depression.Am J Geriatr Psychiatry, vol. 20, no. 8, Aug. 2012, pp. 653–63. Pubmed, doi:10.1097/JGP.0b013e31823e2cc7.
Wang L, Potter GG, Krishnan RKR, Dolcos F, Smith GS, Steffens DC. Neural correlates associated with cognitive decline in late-life depression. Am J Geriatr Psychiatry. 2012 Aug;20(8):653–663.
Journal cover image

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

August 2012

Volume

20

Issue

8

Start / End Page

653 / 663

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Outpatients
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Depression
  • Cognition Disorders