Hl.a-c disparity between patients and unrelated donors (urd) matched for hla-a, -b, and -drb1 alleles by dna typing


Journal Article

High incidences of complications including graft failure, GVHO. and serious infections following URD marrow transplantation despite apparent HLA identity at HLA-A, -B. and DRB1 loci may be due lo genetic disparities at HLA-C locus which currently has 42 alleles. We studied 97 patients and 362 URD to evaluate the extent of HLA-C disparity when URD are identified by serology for HLA-A and -B and by DNA typing for -DRB1 and then to examine whether HLA-A and HLA-B matching by high resolution DNA typing improves the level of HLA-C identity. The DNA typing was performed at MSKCC and serotyping for HLA-A and -B was provided by the registries. Of 362 URD matched by HLA-A and -B serology and by DNA for -DRB1 (j-ABdnaDRBI"), 137, 114, and 111 were 6/6. 5/6. and 4/6 matches, respectively. Of 137 6/6 URD. 82 (59 9%). 47 (34.3%). and 8 (5.8%) were matched for both, one, and none of HLA-C alleles. respectively. In contrast, only 37.7% of the 5/6 and 22.5% of the 4/6 URD were matched for both HLA-C alleles (p<0.01 for both). Following HLA-A and -B DNA typing. 58 of 137 6/6, 42 of 114 5/6, and 32 of 111 4/6 URD remained 6/6, 5/6, and 4/6 matches ("lAiaABDRBl"). respectively. HLA-C disparity between ",sAB

Duke Authors

Cited Authors

  • Prasad, VK

Published Date

  • December 1, 1998

Published In

Volume / Issue

  • 26 / 8

Start / End Page

  • 691 -

International Standard Serial Number (ISSN)

  • 0301-472X

Citation Source

  • Scopus