Spontaneous pregnancy reaches viability after low first trimester serum progesterone: a case report.

Journal Article (Journal Article)

BACKGROUND: Progesterone is produced by the corpus luteum until completion of the luteal-placental shift at approximately 6-10 weeks following last menstruation. Studies have shown that first trimester progesterone levels are predictive of pregnancy viability, and some authors support a level of 5 ng/mL as an absolute threshold to indicate viability. CASE: A 47-year-old woman with recurrent pregnancy loss was noted to have a very low first trimester progesterone level (1.2 ng/mL), but the pregnancy progressed to viability. She unfortunately delivered an intrauterine fetal demise at 27 weeks and 3 days' gestation. CONCLUSION: A single serum progesterone level of < 5 ng/mL is suggestive, but not diagnostic, of a nonviable pregnancy. Routine uterine curettage during the evaluation of a pregnancy of unknown location using this level as an absolute cutoff may result in the interruption of a desired, viable pregnancy.

Full Text

Duke Authors

Cited Authors

  • Crochet, JR; Peavey, MC; Price, TM; Behera, MA

Published Date

  • March 2012

Published In

Volume / Issue

  • 57 / 3-4

Start / End Page

  • 171 - 174

PubMed ID

  • 22523880

International Standard Serial Number (ISSN)

  • 0024-7758


  • eng

Conference Location

  • United States