Epithelioid hemangioma responsive to oral propranolol.

Journal Article (Journal Article)

An 11-year-old boy presented with progressive right-sided proptosis and an orbital mass on neuroimaging. Incisional biopsy revealed an epithelioid hemangioma. The patient underwent an orbitotomy with subtotal excision of the mass. However, the tumor recurred and progressed to the cavernous sinus, despite oral steroids, tacrolimus, and a second subtotal excision. Because of encouraging results reported with beta-blockers in the treatment of pediatric capillary hemangiomas, the patient was subsequently started on oral propranolol, 2 mg/kg/day, with discontinuation of steroids and tacrolimus. A rapid and impressive interval decrease in tumor size was observed, with improvement in proptosis and exposure keratopathy. The patient remains without recurrence approximately 9 months after initiation of propranolol. Our results suggest that oral propranolol may be a potential alternative therapy when complete excision of an epithelioid hemangioma is not practical.

Full Text

Duke Authors

Cited Authors

  • Moss, HB; Sines, DT; Blatt, J; Dutton, JJ; Proia, AD

Published Date

  • July 2012

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • e88 - e90

PubMed ID

  • 22186982

Electronic International Standard Serial Number (EISSN)

  • 1537-2677

Digital Object Identifier (DOI)

  • 10.1097/IOP.0b013e31823645f9


  • eng

Conference Location

  • United States