Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.

Journal Article (Journal Article)

Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxidative stress. We describe 2 patients with ILD associated with exposure to synthetic textile fibers who demonstrated carbon-based ferruginous bodies suggesting an in vivo accumulation of iron by synthetic fibers after deposition in the lung. These iron-laden bodies varied from perfectly linear fibers to almost particulate matter. Linear structures were irregularly interrupted by deposition of iron-abundant material. The capacity of these synthetic fibers to complex iron and generate an oxidative stress is confirmed in vitro.

Full Text

Duke Authors

Cited Authors

  • Ghio, AJ; Funkhouser, W; Pugh, CB; Winters, S; Stonehuerner, JG; Mahar, AM; Roggli, VL

Published Date

  • 2006

Published In

Volume / Issue

  • 34 / 6

Start / End Page

  • 723 - 729

PubMed ID

  • 17074740

International Standard Serial Number (ISSN)

  • 0192-6233

Digital Object Identifier (DOI)

  • 10.1080/01926230600932448


  • eng

Conference Location

  • United States