Skip to main content
Journal cover image

Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.

Publication ,  Journal Article
Ghio, AJ; Funkhouser, W; Pugh, CB; Winters, S; Stonehuerner, JG; Mahar, AM; Roggli, VL
Published in: Toxicol Pathol
2006

Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxidative stress. We describe 2 patients with ILD associated with exposure to synthetic textile fibers who demonstrated carbon-based ferruginous bodies suggesting an in vivo accumulation of iron by synthetic fibers after deposition in the lung. These iron-laden bodies varied from perfectly linear fibers to almost particulate matter. Linear structures were irregularly interrupted by deposition of iron-abundant material. The capacity of these synthetic fibers to complex iron and generate an oxidative stress is confirmed in vitro.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Toxicol Pathol

DOI

ISSN

0192-6233

Publication Date

2006

Volume

34

Issue

6

Start / End Page

723 / 729

Location

United States

Related Subject Headings

  • Toxicology
  • Tomography, X-Ray Computed
  • Textiles
  • Textile Industry
  • Respiratory Function Tests
  • Pulmonary Fibrosis
  • Particle Size
  • Oxidative Stress
  • Oxidants
  • Occupational Exposure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ghio, A. J., Funkhouser, W., Pugh, C. B., Winters, S., Stonehuerner, J. G., Mahar, A. M., & Roggli, V. L. (2006). Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. Toxicol Pathol, 34(6), 723–729. https://doi.org/10.1080/01926230600932448
Ghio, Andrew J., William Funkhouser, Christopher B. Pugh, Scot Winters, Jacqueline G. Stonehuerner, Annabelle M. Mahar, and Victor L. Roggli. “Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.Toxicol Pathol 34, no. 6 (2006): 723–29. https://doi.org/10.1080/01926230600932448.
Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, et al. Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. Toxicol Pathol. 2006;34(6):723–9.
Ghio, Andrew J., et al. “Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.Toxicol Pathol, vol. 34, no. 6, 2006, pp. 723–29. Pubmed, doi:10.1080/01926230600932448.
Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, Roggli VL. Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. Toxicol Pathol. 2006;34(6):723–729.
Journal cover image

Published In

Toxicol Pathol

DOI

ISSN

0192-6233

Publication Date

2006

Volume

34

Issue

6

Start / End Page

723 / 729

Location

United States

Related Subject Headings

  • Toxicology
  • Tomography, X-Ray Computed
  • Textiles
  • Textile Industry
  • Respiratory Function Tests
  • Pulmonary Fibrosis
  • Particle Size
  • Oxidative Stress
  • Oxidants
  • Occupational Exposure