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Functions of cytochrome c in regulation of electron transfer and protein folding.

Publication ,  Journal Article
Ramasarma, T; Rasheed, BK; Vijaya, S; Puranam, RS; Shivaswamy, V; Gaikwad, AS; Kurup, CK
Published in: Indian J Biochem Biophys
April 1992

Cytochrome c, a "mobile electron carrier" of the mitochondrial respiratory chain, also occurs in detectable amounts in the cytosol, and can receive electrons from cytochromes present in endoplasmic reticulum and plasma membranes as well as from superoxide and ascorbate. The pigment was found to dissociate from mitochondrial membranes in liver and kidney when rats were subjected to heat exposure and starvation, respectively. Treating cytochrome c with hydroxylamine gives a partially deaminated product with altered redox properties; decreased stimulation of respiration by deficient mitochondria, increased reduction by superoxide, and complete loss of reducibility by plasma membranes. Mitochondria isolated from brown adipose tissue of cold-exposed rats are found to be sub-saturated with cytochrome c. The ability of cytochrome c to reactivate reduced ribonuclease is now reinterpreted as a molecular chaperone role for the hemoprotein.

Duke Scholars

Published In

Indian J Biochem Biophys

ISSN

0301-1208

Publication Date

April 1992

Volume

29

Issue

2

Start / End Page

173 / 178

Location

India

Related Subject Headings

  • Subcellular Fractions
  • Protein Conformation
  • Models, Biological
  • Mitochondria, Liver
  • Mitochondria
  • Kidney
  • Electron Transport
  • Cytosol
  • Cytochrome c Group
  • Biochemistry & Molecular Biology
 

Citation

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Ramasarma, T., Rasheed, B. K., Vijaya, S., Puranam, R. S., Shivaswamy, V., Gaikwad, A. S., & Kurup, C. K. (1992). Functions of cytochrome c in regulation of electron transfer and protein folding. Indian J Biochem Biophys, 29(2), 173–178.
Ramasarma, T., B. K. Rasheed, S. Vijaya, R. S. Puranam, V. Shivaswamy, A. S. Gaikwad, and C. K. Kurup. “Functions of cytochrome c in regulation of electron transfer and protein folding.Indian J Biochem Biophys 29, no. 2 (April 1992): 173–78.
Ramasarma T, Rasheed BK, Vijaya S, Puranam RS, Shivaswamy V, Gaikwad AS, et al. Functions of cytochrome c in regulation of electron transfer and protein folding. Indian J Biochem Biophys. 1992 Apr;29(2):173–8.
Ramasarma, T., et al. “Functions of cytochrome c in regulation of electron transfer and protein folding.Indian J Biochem Biophys, vol. 29, no. 2, Apr. 1992, pp. 173–78.
Ramasarma T, Rasheed BK, Vijaya S, Puranam RS, Shivaswamy V, Gaikwad AS, Kurup CK. Functions of cytochrome c in regulation of electron transfer and protein folding. Indian J Biochem Biophys. 1992 Apr;29(2):173–178.

Published In

Indian J Biochem Biophys

ISSN

0301-1208

Publication Date

April 1992

Volume

29

Issue

2

Start / End Page

173 / 178

Location

India

Related Subject Headings

  • Subcellular Fractions
  • Protein Conformation
  • Models, Biological
  • Mitochondria, Liver
  • Mitochondria
  • Kidney
  • Electron Transport
  • Cytosol
  • Cytochrome c Group
  • Biochemistry & Molecular Biology