Rapid remodeling of sensory endings in the corneas of living mice.

Journal Article (Journal Article)

The terminals of trigeminal neurons were followed over time in the corneas of living mice by repeated staining with a nontoxic fluorescent dye. The purpose of these observations was to evaluate remodeling of sensory nerve endings in an adult mammal. Video images of topically stained nerve endings within particular corneal regions were recorded initially, and then again after intervals ranging from 4 hr to 30 d. Comparison of the 2 sets of images showed that sensory endings in the corneal epithelium undergo continual rearrangement under normal circumstances. Substantial changes in terminal configuration occurred over periods as brief as a day.

Full Text

Duke Authors

Cited Authors

  • Harris, LW; Purves, D

Published Date

  • June 1989

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 2210 - 2214

PubMed ID

  • 2723770

Pubmed Central ID

  • PMC6569726

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.09-06-02210.1989


  • eng