The changing view of neural specificity.

Journal Article (Journal Article)

The generation of specific patterns of neuronal connections has usually been regarded as a central problem in neurobiology. The prevailing view for many years has been that these connections are established by complementary recognition molecules on the pre- and postsynaptic cells (the chemoaffinity theory). Experimental results obtained in the past decade, however, indicate that the view that axon guidance and synaptogenesis proceed according to restrictive chemical markers is too narrow. Although a more rigid plan may prevail in some invertebrates, the formation of specific connections in vertebrates also involves competition between axon terminals, trophic feedback between pre- and postsynaptic cells, and modification of connections by functional activity.

Full Text

Duke Authors

Cited Authors

  • Easter, SS; Purves, D; Rakic, P; Spitzer, NC

Published Date

  • November 1985

Published In

Volume / Issue

  • 230 / 4725

Start / End Page

  • 507 - 511

PubMed ID

  • 4048944

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.4048944


  • eng