Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy.

Journal Article (Journal Article)

OBJECTIVE: Because leptin, the adipocyte-derived hormone, affects thymocyte survival, proliferation of naïve T lymphocytes and the production of proinflammatory cytokines, we aimed to investigate the role of this molecule in immunoreconstitution during highly active antiretroviral therapy (HAART). DESIGN: Prospective longitudinal cohort study. A series of 20 HIV+ children were studied. The subjects were grouped by their increase in serum leptin levels after HAART. METHODS: All participants were weight-stable, free of endocrine disorders and opportunistic infections and equally distributed for sex (males, n=10; females, n=10). Body mass index (BMI), serum lipids, leptin, CD4+ T cells and HIV-1 RNA were measured before initiation of HAART and after a 2-year follow-up. RESULTS: Serum leptin concentration positively correlated with CD4+ lymphocyte number before treatment. HAART significantly reduced viraemia and increased serum levels of lipids in all patients, whereas a significant increase in CD4+ cells and serum leptin was observed in the majority of patients. Notably, in children where HAART was not effective in increasing CD4+ lymphocyte counts, serum leptin did not increase. CONCLUSION: To our knowledge, these findings reveal for the first time a novel link among CD4+ T lymphocytes, serum leptin and highly active anteretroviral theraphy.

Full Text

Duke Authors

Cited Authors

  • Matarese, G; Castelli-Gattinara, G; Cancrini, C; Bernardi, S; Romiti, ML; Savarese, C; Di Giacomo, A; Rossi, P; Racioppi, L

Published Date

  • November 2002

Published In

Volume / Issue

  • 57 / 5

Start / End Page

  • 643 - 646

PubMed ID

  • 12390339

International Standard Serial Number (ISSN)

  • 0300-0664

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2265.2002.01634.x


  • eng

Conference Location

  • England