Scholars@Duke publication: Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia.

Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia.

Publication , Journal Article

Cancrini, C; Romiti, ML; Di Cesare, S; Angelini, F; Gigliotti, D; Livadiotti, S; Bertini, E; Rossi, P; Racioppi, L

Published in: Scand J Immunol

August 2002

Molecular analysis of T-cell receptor (TCR) repertoire, by measuring the CDR3 heterogeneity length of beta-variable regions (spectratyping), is useful for acquiring novel information on the status of immune system in primary immunodeficiency. Here, we evaluate TCR repertoire in a child with trichothiodystrophy (TTD) and combined immunodeficiency (CID). Spectratyping revealed marked alterations of TCR repertoire distribution: 21 and 10 out of 27 TCR Vbeta (TCRBV) families and subfamilies were skewed in CD8+ and CD4+ subsets, respectively. These findings revealed, for the first time in a TTD patient with CID, a marked reduction in the TCR repertoire complexity, which may reflect alterations in the mechanisms regulating the generation and homeostasis of T cells.

Duke Scholars

Author Luigi Racioppi Medicine, Hematologic Malignancies and Cellular Therapy

Published In

Scand J Immunol

DOI

10.1046/j.1365-3083.2002.01122.x

ISSN

0300-9475

Publication Date

August 2002

Volume

Issue

Start / End Page

212 / 216

Location

England

Related Subject Headings

Receptors, Antigen, T-Cell
Male
Lymphopenia
Immunology
Humans
Hair Diseases
Gene Rearrangement, T-Lymphocyte
Child, Preschool
Case-Control Studies
CD4-Positive T-Lymphocytes

Citation

APA

Chicago

ICMJE

MLA

NLM

Cancrini, C., Romiti, M. L., Di Cesare, S., Angelini, F., Gigliotti, D., Livadiotti, S., … Racioppi, L. (2002). Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia. Scand J Immunol, 56(2), 212–216. https://doi.org/10.1046/j.1365-3083.2002.01122.x

Cancrini, C., M. L. Romiti, S. Di Cesare, F. Angelini, D. Gigliotti, S. Livadiotti, E. Bertini, P. Rossi, and L. Racioppi. “Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia.” Scand J Immunol 56, no. 2 (August 2002): 212–16. https://doi.org/10.1046/j.1365-3083.2002.01122.x.

Cancrini C, Romiti ML, Di Cesare S, Angelini F, Gigliotti D, Livadiotti S, et al. Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia. Scand J Immunol. 2002 Aug;56(2):212–6.

Cancrini, C., et al. “Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia.” Scand J Immunol, vol. 56, no. 2, Aug. 2002, pp. 212–16. Pubmed, doi:10.1046/j.1365-3083.2002.01122.x.

Cancrini C, Romiti ML, Di Cesare S, Angelini F, Gigliotti D, Livadiotti S, Bertini E, Rossi P, Racioppi L. Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia. Scand J Immunol. 2002 Aug;56(2):212–216.

Published In

Scand J Immunol

DOI

10.1046/j.1365-3083.2002.01122.x

ISSN

0300-9475

Publication Date

August 2002

Volume

Issue

Start / End Page

212 / 216

Location

England

Related Subject Headings

Receptors, Antigen, T-Cell
Male
Lymphopenia
Immunology
Humans
Hair Diseases
Gene Rearrangement, T-Lymphocyte
Child, Preschool
Case-Control Studies
CD4-Positive T-Lymphocytes