Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.

Published

Journal Article

Immune parameters were analyzed in peripheral blood mononuclear cells (PBMC) and cervical mucosa biopsy specimens of human immunodeficiency virus (HIV)-seronegative women sexually exposed to HIV (exposed seronegative [ESN]), HIV-infected women, and healthy women without HIV exposure. HIV was not detected in PBMC or cervical mucosa biopsy specimens of ESN women. However, interleukin (IL)-6, IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV-infected women; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV-infected women; HIV-specific IFN-gamma-secreting cells were detected in vaginal washes of ESN and HIV-infected women; and phenotypic alterations were present in PBMC of ESN women. These results suggest that active HIV infection is not required for T cell activation; immune alterations occur in women in whom HIV infection cannot be detected virologically or clinically.

Full Text

Duke Authors

Cited Authors

  • Biasin, M; Caputo, SL; Speciale, L; Colombo, F; Racioppi, L; Zagliani, A; Blé, C; Vichi, F; Cianferoni, L; Masci, AM; Villa, ML; Ferrante, P; Mazzotta, F; Clerici, M

Published Date

  • November 2000

Published In

Volume / Issue

  • 182 / 5

Start / End Page

  • 1365 - 1374

PubMed ID

  • 11023460

Pubmed Central ID

  • 11023460

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/315873

Language

  • eng