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Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.

Publication ,  Journal Article
Biasin, M; Caputo, SL; Speciale, L; Colombo, F; Racioppi, L; Zagliani, A; Blé, C; Vichi, F; Cianferoni, L; Masci, AM; Villa, ML; Ferrante, P ...
Published in: J Infect Dis
November 2000

Immune parameters were analyzed in peripheral blood mononuclear cells (PBMC) and cervical mucosa biopsy specimens of human immunodeficiency virus (HIV)-seronegative women sexually exposed to HIV (exposed seronegative [ESN]), HIV-infected women, and healthy women without HIV exposure. HIV was not detected in PBMC or cervical mucosa biopsy specimens of ESN women. However, interleukin (IL)-6, IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV-infected women; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV-infected women; HIV-specific IFN-gamma-secreting cells were detected in vaginal washes of ESN and HIV-infected women; and phenotypic alterations were present in PBMC of ESN women. These results suggest that active HIV infection is not required for T cell activation; immune alterations occur in women in whom HIV infection cannot be detected virologically or clinically.

Duke Scholars

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

November 2000

Volume

182

Issue

5

Start / End Page

1365 / 1374

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, CXCR4
  • Receptors, CCR5
  • RNA, Messenger
  • Microbiology
  • Lymphocyte Activation
  • Leukocytes, Mononuclear
  • Interferon-gamma
  • Immunophenotyping
  • Immunity, Mucosal
 

Citation

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Chicago
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MLA
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Biasin, M., Caputo, S. L., Speciale, L., Colombo, F., Racioppi, L., Zagliani, A., … Clerici, M. (2000). Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J Infect Dis, 182(5), 1365–1374. https://doi.org/10.1086/315873
Biasin, M., S. L. Caputo, L. Speciale, F. Colombo, L. Racioppi, A. Zagliani, C. Blé, et al. “Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.J Infect Dis 182, no. 5 (November 2000): 1365–74. https://doi.org/10.1086/315873.
Biasin M, Caputo SL, Speciale L, Colombo F, Racioppi L, Zagliani A, et al. Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J Infect Dis. 2000 Nov;182(5):1365–74.
Biasin, M., et al. “Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.J Infect Dis, vol. 182, no. 5, Nov. 2000, pp. 1365–74. Pubmed, doi:10.1086/315873.
Biasin M, Caputo SL, Speciale L, Colombo F, Racioppi L, Zagliani A, Blé C, Vichi F, Cianferoni L, Masci AM, Villa ML, Ferrante P, Mazzotta F, Clerici M. Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J Infect Dis. 2000 Nov;182(5):1365–1374.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

November 2000

Volume

182

Issue

5

Start / End Page

1365 / 1374

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, CXCR4
  • Receptors, CCR5
  • RNA, Messenger
  • Microbiology
  • Lymphocyte Activation
  • Leukocytes, Mononuclear
  • Interferon-gamma
  • Immunophenotyping
  • Immunity, Mucosal