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Interactions between sleep and epilepsy.

Publication ,  Journal Article
Méndez, M; Radtke, RA
Published in: J Clin Neurophysiol
March 2001

Sleep is one of the best-documented factors influencing the expression of seizures and interictal discharges. Janz studied the relation between seizures and the sleep/wake cycle and divided the epilepsies into three categories: nocturnal, awakening, and diffuse. Since then, the effect of sleep on the ictal and interictal manifestations of epilepsy has been studied extensively. Many seizures are activated by sleep or arousal from sleep. Interictal discharges are also seen more commonly during sleep, with the greatest activation seen during nonrapid eye movement sleep. Sleep not only increases the frequency of epileptiform abnormalities, but also may alter their morphology and distribution. Sleep deprivation also facilitates both epileptiform abnormalities and seizures. Seizures, on the other hand, also impact sleep. Epileptic patients demonstrate multiple sleep abnormalities, including an increased sleep latency, fragmented sleep, increased awakenings and stage shifts, and an increase in stages 1 and 2 of nonrapid eye movement sleep. These disturbances may in turn be modulated by antiepileptic treatment. This review summarizes the interactions between sleep and epilepsy, including the timing of seizures during the sleep/wake cycle, the influence of sleep on various seizure disorders, the effects of sleep deprivation, and the changes in sleep patterns caused by seizures and their treatment.

Duke Scholars

Published In

J Clin Neurophysiol

DOI

ISSN

0736-0258

Publication Date

March 2001

Volume

18

Issue

2

Start / End Page

106 / 127

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Spasms, Infantile
  • Sleep Wake Disorders
  • Sleep Deprivation
  • Sleep
  • Seizures
  • Neurology & Neurosurgery
  • Landau-Kleffner Syndrome
  • Infant
  • Humans
 

Citation

APA
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ICMJE
MLA
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Méndez, M., & Radtke, R. A. (2001). Interactions between sleep and epilepsy. J Clin Neurophysiol, 18(2), 106–127. https://doi.org/10.1097/00004691-200103000-00003
Méndez, M., and R. A. Radtke. “Interactions between sleep and epilepsy.J Clin Neurophysiol 18, no. 2 (March 2001): 106–27. https://doi.org/10.1097/00004691-200103000-00003.
Méndez M, Radtke RA. Interactions between sleep and epilepsy. J Clin Neurophysiol. 2001 Mar;18(2):106–27.
Méndez, M., and R. A. Radtke. “Interactions between sleep and epilepsy.J Clin Neurophysiol, vol. 18, no. 2, Mar. 2001, pp. 106–27. Pubmed, doi:10.1097/00004691-200103000-00003.
Méndez M, Radtke RA. Interactions between sleep and epilepsy. J Clin Neurophysiol. 2001 Mar;18(2):106–127.

Published In

J Clin Neurophysiol

DOI

ISSN

0736-0258

Publication Date

March 2001

Volume

18

Issue

2

Start / End Page

106 / 127

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Spasms, Infantile
  • Sleep Wake Disorders
  • Sleep Deprivation
  • Sleep
  • Seizures
  • Neurology & Neurosurgery
  • Landau-Kleffner Syndrome
  • Infant
  • Humans