Mechanisms of CaMKII action in long-term potentiation.


Journal Article (Review)

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds to NMDA-type glutamate receptors and produces potentiation by phosphorylating principal and auxiliary subunits of AMPA-type glutamate receptors. These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse.

Full Text

Cited Authors

  • Lisman, J; Yasuda, R; Raghavachari, S

Published Date

  • February 15, 2012

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 169 - 182

PubMed ID

  • 22334212

Pubmed Central ID

  • 22334212

Electronic International Standard Serial Number (EISSN)

  • 1471-0048

International Standard Serial Number (ISSN)

  • 1471-003X

Digital Object Identifier (DOI)

  • 10.1038/nrn3192


  • eng