The sequence of events that underlie quantal transmission at central glutamatergic synapses.


Journal Article (Review)

The properties of synaptic transmission were first elucidated at the neuromuscular junction. More recent work has examined transmission at synapses within the brain. Here we review the remarkable progress in understanding the biophysical and molecular basis of the sequential steps in this process. These steps include the elevation of Ca2+ in microdomains of the presynaptic terminal, the diffusion of transmitter through the fusion pore into the synaptic cleft and the activation of postsynaptic receptors. The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity.

Full Text

Cited Authors

  • Lisman, JE; Raghavachari, S; Tsien, RW

Published Date

  • August 2007

Published In

Volume / Issue

  • 8 / 8

Start / End Page

  • 597 - 609

PubMed ID

  • 17637801

Pubmed Central ID

  • 17637801

Electronic International Standard Serial Number (EISSN)

  • 1471-0048

International Standard Serial Number (ISSN)

  • 1471-003X

Digital Object Identifier (DOI)

  • 10.1038/nrn2191


  • eng