The sequence of events that underlie quantal transmission at central glutamatergic synapses.
Publication
, Journal Article
Lisman, JE; Raghavachari, S; Tsien, RW
Published in: Nature reviews. Neuroscience
August 2007
The properties of synaptic transmission were first elucidated at the neuromuscular junction. More recent work has examined transmission at synapses within the brain. Here we review the remarkable progress in understanding the biophysical and molecular basis of the sequential steps in this process. These steps include the elevation of Ca2+ in microdomains of the presynaptic terminal, the diffusion of transmitter through the fusion pore into the synaptic cleft and the activation of postsynaptic receptors. The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity.
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Published In
Nature reviews. Neuroscience
DOI
EISSN
1471-0048
ISSN
1471-003X
Publication Date
August 2007
Volume
8
Issue
8
Start / End Page
597 / 609
Related Subject Headings
- Synaptic Vesicles
- Synaptic Transmission
- Synaptic Membranes
- Synapses
- Receptors, AMPA
- Neurology & Neurosurgery
- Membrane Fusion
- Humans
- Glutamic Acid
- Calcium Signaling
Citation
APA
Chicago
ICMJE
MLA
NLM
Lisman, J. E., Raghavachari, S., & Tsien, R. W. (2007). The sequence of events that underlie quantal transmission at central glutamatergic synapses. Nature Reviews. Neuroscience, 8(8), 597–609. https://doi.org/10.1038/nrn2191
Lisman, John E., Sridhar Raghavachari, and Richard W. Tsien. “The sequence of events that underlie quantal transmission at central glutamatergic synapses.” Nature Reviews. Neuroscience 8, no. 8 (August 2007): 597–609. https://doi.org/10.1038/nrn2191.
Lisman JE, Raghavachari S, Tsien RW. The sequence of events that underlie quantal transmission at central glutamatergic synapses. Nature reviews Neuroscience. 2007 Aug;8(8):597–609.
Lisman, John E., et al. “The sequence of events that underlie quantal transmission at central glutamatergic synapses.” Nature Reviews. Neuroscience, vol. 8, no. 8, Aug. 2007, pp. 597–609. Epmc, doi:10.1038/nrn2191.
Lisman JE, Raghavachari S, Tsien RW. The sequence of events that underlie quantal transmission at central glutamatergic synapses. Nature reviews Neuroscience. 2007 Aug;8(8):597–609.
Published In
Nature reviews. Neuroscience
DOI
EISSN
1471-0048
ISSN
1471-003X
Publication Date
August 2007
Volume
8
Issue
8
Start / End Page
597 / 609
Related Subject Headings
- Synaptic Vesicles
- Synaptic Transmission
- Synaptic Membranes
- Synapses
- Receptors, AMPA
- Neurology & Neurosurgery
- Membrane Fusion
- Humans
- Glutamic Acid
- Calcium Signaling