Safety considerations in the use of drug combinations during general anaesthesia.

Journal Article (Journal Article;Review)

The most commonly employed technique for providing general anaesthesia uses a balanced approach, where different drugs are used to reach specific desired endpoints. The variety of drugs used can result in a dozen or more different compounds being administered during a 'routine anaesthetic' procedure. Drug interactions are quite common and their clinical effects can be very significant. Clinically, general anaesthesia has 4 goals. These are: unconsciousness/amnesia; analgesia; muscle relaxation and maintenance of homeostasis. The anaesthesiologist tries to select only those drugs that permit a rapid onset of desirable operative conditions so that surgery can be performed properly and rapidly. Such drugs should also minimally disturb the patient's preoperative homeostatic maintenance, and maximise return to a desirable postanaesthetic functional state.

Full Text

Duke Authors

Cited Authors

  • Ransom, ES; Mueller, RA

Published Date

  • February 1997

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 88 - 103

PubMed ID

  • 9067121

International Standard Serial Number (ISSN)

  • 0114-5916

Digital Object Identifier (DOI)

  • 10.2165/00002018-199716020-00002


  • eng

Conference Location

  • New Zealand