Regulation of cerebral glucose metabolism.

Published

Journal Article (Review)

The brain uses glucose as a primary fuel for energy generation. Glucose gains entry into the brain by facilitated diffusion across the blood-brain barrier. Glucose transport may adapt during changes in cerebral glucose metabolism, neural activation and changes in plasma glucose levels. Within the brain, glucose is either oxidized to produce ATP or used to synthesize glycogen. To ensure the delivery of a continuous supply of glucose to maintain normal cellular function, the brain has developed a complex regulatory system to preserve its supply. Gluco-sensing neurons have been demonstrated in various regions of the brain and they appear to play an important role in not only detecting changes in brain glucose levels but also in initiating responses to maintain constant brain glucose levels. In this review, we will discuss the regulation of brain glucose metabolism (CMR(gluc)) and how it adapts to chronic changes in glycemia, like that seen in hyperglycemic patients with diabetes mellitus or patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness. We will also consider the role of brain glycogen in providing fuel for energy under conditions of stress.

Full Text

Duke Authors

Cited Authors

  • Rao, J; Oz, G; Seaquist, ER

Published Date

  • June 2006

Published In

Volume / Issue

  • 31 / 2

Start / End Page

  • 149 - 158

PubMed ID

  • 16682938

Pubmed Central ID

  • 16682938

International Standard Serial Number (ISSN)

  • 0391-1977

Language

  • eng

Conference Location

  • Italy