Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.

Published

Journal Article

The metabolic differences between B-NHL and primary human B cells are poorly understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion lymphoma (PEL) is a unique subset that is linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). We report that the metabolic profiles of primary B cells are significantly different from that of PEL. Compared with primary B cells, both aerobic glycolysis and fatty acid synthesis (FAS) are up-regulated in PEL and other types of nonviral B-NHL. We found that aerobic glycolysis and FAS occur in a PI3K-dependent manner and appear to be interdependent. PEL overexpress the fatty acid synthesizing enzyme, FASN, and both PEL and other B-NHL were much more sensitive to the FAS inhibitor, C75, than primary B cells. Our findings suggest that FASN may be a unique candidate for molecular targeted therapy against PEL and other B-NHL.

Full Text

Duke Authors

Cited Authors

  • Bhatt, AP; Jacobs, SR; Freemerman, AJ; Makowski, L; Rathmell, JC; Dittmer, DP; Damania, B

Published Date

  • July 17, 2012

Published In

Volume / Issue

  • 109 / 29

Start / End Page

  • 11818 - 11823

PubMed ID

  • 22752304

Pubmed Central ID

  • 22752304

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1205995109

Language

  • eng

Conference Location

  • United States