Metabolic pathways in T cell fate and function.

Journal Article (Journal Article;Review)

T cell growth and function must be tightly regulated to provide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T cell metabolism is highly dynamic and has a tremendous impact on the ability of T cells to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors that must support specific cell functions, as effector, regulatory, memory, and alloreactive T cells have distinct metabolic needs in immunity and inflammation. Here, we review the signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with T cell function. Ultimately, these metabolic differences may provide new opportunities to modulate the immune response and treat inflammatory and autoimmune diseases.

Full Text

Duke Authors

Cited Authors

  • Gerriets, VA; Rathmell, JC

Published Date

  • April 2012

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 168 - 173

PubMed ID

  • 22342741

Pubmed Central ID

  • PMC3319512

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England