PKM2 and the tricky balance of growth and energy in cancer.


Journal Article

In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.

Full Text

Duke Authors

Cited Authors

  • Macintyre, AN; Rathmell, JC

Published Date

  • June 24, 2011

Published In

Volume / Issue

  • 42 / 6

Start / End Page

  • 713 - 714

PubMed ID

  • 21700216

Pubmed Central ID

  • 21700216

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2011.06.003


  • eng

Conference Location

  • United States