Akt1 and Akt2 promote peripheral B-cell maturation and survival.

Published

Journal Article

Although the 3 isoforms of Akt regulate cell growth, proliferation, and survival in a wide variety of cell types, their role in B-cell development is unknown. We assessed B-cell maturation in the bone marrow (BM) and periphery in chimeras established with fetal liver progenitors lacking Akt1 and/or Akt2. We found that the generation of marginal zone (MZ) and B1 B cells, 2 key sources of antibacterial antibodies, was highly dependent on the combined expression of Akt1 and Akt2. In contrast, Akt1/2 deficiency did not negatively affect the generation of transitional or mature follicular B cells in the periphery or their precursors in the BM. However, Akt1/2-deficient follicular B cells exhibited a profound survival defect when forced to compete against wild-type B cells in vivo. Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival.

Full Text

Duke Authors

Cited Authors

  • Calamito, M; Juntilla, MM; Thomas, M; Northrup, DL; Rathmell, J; Birnbaum, MJ; Koretzky, G; Allman, D

Published Date

  • May 20, 2010

Published In

Volume / Issue

  • 115 / 20

Start / End Page

  • 4043 - 4050

PubMed ID

  • 20042722

Pubmed Central ID

  • 20042722

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

Digital Object Identifier (DOI)

  • 10.1182/blood-2009-09-241638

Language

  • eng

Conference Location

  • United States