TGF-beta: a new role for an old AktTOR.
Journal Article (Journal Article)
Nutrient overabundance is known to promote cellular hypertrophy, a significant pathological event in diseases like diabetes and cancer, although mechanisms have remained unclear. In this issue of Developmental Cell, Wu and Derynck provide a new model that links metabolism and cell growth by demonstrating that hyperglycemia can increase TGF-beta-dependent activation of the mTOR pathway to promote cellular hyperplasia.
Full Text
Duke Authors
Cited Authors
- Goraksha-Hicks, P; Rathmell, JC
Published Date
- July 2009
Published In
Volume / Issue
- 17 / 1
Start / End Page
- 6 - 8
PubMed ID
- 19619487
Pubmed Central ID
- PMC2789270
Electronic International Standard Serial Number (EISSN)
- 1878-1551
Digital Object Identifier (DOI)
- 10.1016/j.devcel.2009.07.004
Language
- eng
Conference Location
- United States