TGF-beta: a new role for an old AktTOR.

Journal Article (Journal Article)

Nutrient overabundance is known to promote cellular hypertrophy, a significant pathological event in diseases like diabetes and cancer, although mechanisms have remained unclear. In this issue of Developmental Cell, Wu and Derynck provide a new model that links metabolism and cell growth by demonstrating that hyperglycemia can increase TGF-beta-dependent activation of the mTOR pathway to promote cellular hyperplasia.

Full Text

Duke Authors

Cited Authors

  • Goraksha-Hicks, P; Rathmell, JC

Published Date

  • July 2009

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 6 - 8

PubMed ID

  • 19619487

Pubmed Central ID

  • PMC2789270

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2009.07.004


  • eng

Conference Location

  • United States