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Immunology of vascularized composite allotransplantation: a primer for hand surgeons.

Publication ,  Journal Article
Ravindra, K; Haeberle, M; Levin, LS; Ildstad, ST
Published in: J Hand Surg Am
April 2012

Vascularized composite allotransplantation is a recent innovation in the fields of transplantation surgery, plastic and reconstructive surgery, and orthopedic surgery. The success of hand and face transplantation has been based on extensive experience in solid organ transplantation. Advances in understanding the immunology of transplantation have had a major role in achieving excellent results in this new field. The purpose of this article is to introduce the basics of human immunology (innate and adaptive systems) and the immunological basis of human transplantation (the importance of human leukocyte antigen, direct and indirect pathways of antigen recognition, the 3 signals for T-cell activation, and mechanisms and types of allograft rejection) and focus on the mode of action of immunosuppressive drugs that have evolved as the mechanisms and pathways for rejection have been defined through research. This includes recent studies involving the use of costimulatory blockade, regulatory T cells, and tolerance induction that have resulted from research in understanding the mechanisms of immune recognition and function.

Duke Scholars

Published In

J Hand Surg Am

DOI

EISSN

1531-6564

Publication Date

April 2012

Volume

37

Issue

4

Start / End Page

842 / 850

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • T-Lymphocytes, Regulatory
  • Self Tolerance
  • Receptors, Antigen, T-Cell
  • Orthopedics
  • Major Histocompatibility Complex
  • Immunity, Innate
  • Humans
  • Hand Transplantation
 

Citation

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ICMJE
MLA
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Ravindra, K., Haeberle, M., Levin, L. S., & Ildstad, S. T. (2012). Immunology of vascularized composite allotransplantation: a primer for hand surgeons. J Hand Surg Am, 37(4), 842–850. https://doi.org/10.1016/j.jhsa.2012.01.042
Ravindra, K., M. Haeberle, L. S. Levin, and S. T. Ildstad. “Immunology of vascularized composite allotransplantation: a primer for hand surgeons.J Hand Surg Am 37, no. 4 (April 2012): 842–50. https://doi.org/10.1016/j.jhsa.2012.01.042.
Ravindra K, Haeberle M, Levin LS, Ildstad ST. Immunology of vascularized composite allotransplantation: a primer for hand surgeons. J Hand Surg Am. 2012 Apr;37(4):842–50.
Ravindra, K., et al. “Immunology of vascularized composite allotransplantation: a primer for hand surgeons.J Hand Surg Am, vol. 37, no. 4, Apr. 2012, pp. 842–50. Pubmed, doi:10.1016/j.jhsa.2012.01.042.
Ravindra K, Haeberle M, Levin LS, Ildstad ST. Immunology of vascularized composite allotransplantation: a primer for hand surgeons. J Hand Surg Am. 2012 Apr;37(4):842–850.
Journal cover image

Published In

J Hand Surg Am

DOI

EISSN

1531-6564

Publication Date

April 2012

Volume

37

Issue

4

Start / End Page

842 / 850

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • T-Lymphocytes, Regulatory
  • Self Tolerance
  • Receptors, Antigen, T-Cell
  • Orthopedics
  • Major Histocompatibility Complex
  • Immunity, Innate
  • Humans
  • Hand Transplantation