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Composite tissue transplantation: a rapidly advancing field.

Publication ,  Journal Article
Ravindra, KV; Wu, S; Bozulic, L; Xu, H; Breidenbach, WC; Ildstad, ST
Published in: Transplant Proc
June 2008

Composite tissue allotransplantation (CTA) is emerging as a potential treatment for complex tissue defects. It is currently being performed with increasing frequency in the clinic. The feasibility of the procedure has been confirmed through 30 hand transplantation, 3 facial reconstructions, and vascularized knee, esophageal, and tracheal allografts. A major drawback for CTA is the requirement for lifelong immunosuppression. The toxicity of these agents has limited the widespread application of CTA. Methods to reduce or eliminate the requirement for immunosuppression and promote CTA acceptance would represent a significant step forward in the field. Multiple studies suggest that mixed chimerism established by bone marrow transplantation promotes tolerance resulting in allograft acceptance. This overview focuses on the history and the exponentially expanding applications of the new frontier in CTA transplantation: immunology associated with CTA; preclinical animal models of CTA; clinical experience with CTA; and advances in mixed chimerism-induced tolerance in CTA. Additionally, some important hurdles that must be overcome in using bone marrow chimerism to induce tolerance to CTA are also discussed.

Duke Scholars

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Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

June 2008

Volume

40

Issue

5

Start / End Page

1237 / 1248

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Transplantation
  • Tissue Donors
  • Tendons
  • Muscle, Skeletal
  • Models, Animal
  • Major Histocompatibility Complex
  • Leg
  • Larynx
 

Citation

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Ravindra, K. V., Wu, S., Bozulic, L., Xu, H., Breidenbach, W. C., & Ildstad, S. T. (2008). Composite tissue transplantation: a rapidly advancing field. Transplant Proc, 40(5), 1237–1248. https://doi.org/10.1016/j.transproceed.2008.04.003
Ravindra, K. V., S. Wu, L. Bozulic, H. Xu, W. C. Breidenbach, and S. T. Ildstad. “Composite tissue transplantation: a rapidly advancing field.Transplant Proc 40, no. 5 (June 2008): 1237–48. https://doi.org/10.1016/j.transproceed.2008.04.003.
Ravindra KV, Wu S, Bozulic L, Xu H, Breidenbach WC, Ildstad ST. Composite tissue transplantation: a rapidly advancing field. Transplant Proc. 2008 Jun;40(5):1237–48.
Ravindra, K. V., et al. “Composite tissue transplantation: a rapidly advancing field.Transplant Proc, vol. 40, no. 5, June 2008, pp. 1237–48. Pubmed, doi:10.1016/j.transproceed.2008.04.003.
Ravindra KV, Wu S, Bozulic L, Xu H, Breidenbach WC, Ildstad ST. Composite tissue transplantation: a rapidly advancing field. Transplant Proc. 2008 Jun;40(5):1237–1248.
Journal cover image

Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

June 2008

Volume

40

Issue

5

Start / End Page

1237 / 1248

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Transplantation
  • Tissue Donors
  • Tendons
  • Muscle, Skeletal
  • Models, Animal
  • Major Histocompatibility Complex
  • Leg
  • Larynx