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Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis.

Publication ,  Journal Article
Raynor, EM; Butler, A; Guill, M; Bent, JP
Published in: Arch Otolaryngol Head Neck Surg
May 2000

OBJECTIVE: To determine the benefit of nasally inhaled dornase alfa in cystic fibrosis (CF) sinusitis. DESIGN: Retrospective chart review comparing postsurgical course, radiographic studies, and pulmonary function test results in patients who were treated with nasally inhaled dornase alfa with those in patients who were not treated with dornase alfa. PATIENTS: Twenty consecutive patients with CF who underwent functional endoscopic sinus surgery from 1993 to 1997 were included in the study. Treatment with nasally inhaled dornase alfa was initiated in 5 of the 20 patients after they underwent functional endoscopic sinus surgery. SETTING: Tertiary care academic center. RESULTS: The dornase alfa-treated patients had less mucosal edema and no polyps at serial endoscopy over 3 years compared with the non-dornase alfa-treated patients. The patients who received nasally inhaled dornase alfa also underwent fewer revision functional endoscopic sinus surgical procedures (1.6 vs 3.2), even though there was essentially no change in pulmonary function test results in these patients. CONCLUSIONS: Sinusitis continues to be a major cause of morbidity in patients with CF. Symptomatic patients frequently require multiple drug regimens, including long-term systemic antibiotic therapy, topical and systemic steroid therapy, and antibiotic nasal irrigations. This preliminary study indicates the potential impact of nasally inhaled dornase alfa in controlling postoperative symptoms in CF sinusitis.

Duke Scholars

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

May 2000

Volume

126

Issue

5

Start / End Page

581 / 583

Location

United States

Related Subject Headings

  • Sinusitis
  • Retrospective Studies
  • Recombinant Proteins
  • Postoperative Complications
  • Otorhinolaryngology
  • Nasal Polyps
  • Male
  • Humans
  • Female
  • Expectorants
 

Citation

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Raynor, E. M., Butler, A., Guill, M., & Bent, J. P. (2000). Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis. Arch Otolaryngol Head Neck Surg, 126(5), 581–583. https://doi.org/10.1001/archotol.126.5.581
Raynor, E. M., A. Butler, M. Guill, and J. P. Bent. “Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis.Arch Otolaryngol Head Neck Surg 126, no. 5 (May 2000): 581–83. https://doi.org/10.1001/archotol.126.5.581.
Raynor EM, Butler A, Guill M, Bent JP. Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2000 May;126(5):581–3.
Raynor, E. M., et al. “Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis.Arch Otolaryngol Head Neck Surg, vol. 126, no. 5, May 2000, pp. 581–83. Pubmed, doi:10.1001/archotol.126.5.581.
Raynor EM, Butler A, Guill M, Bent JP. Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2000 May;126(5):581–583.

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

May 2000

Volume

126

Issue

5

Start / End Page

581 / 583

Location

United States

Related Subject Headings

  • Sinusitis
  • Retrospective Studies
  • Recombinant Proteins
  • Postoperative Complications
  • Otorhinolaryngology
  • Nasal Polyps
  • Male
  • Humans
  • Female
  • Expectorants