An assessment of cochlear hair-cell loss in insulin-dependent diabetes mellitus diabetic and noise-exposed rats.

Journal Article (Journal Article)


The purpose of this study was to investigate if insulin-dependent diabetes mellitus causes degenerative changes in the inner ear and whether these changes are exacerbated by noise exposure.


Insulin-dependent diabetes mellitus was induced in male rats using streptozotocin (65 mg/kg of body weight, intravenously). Half the animals were exposed to 95 dB of random noise for 12 hours per day over a period of 6 months. The cochleae were removed, fixed, decalcified, dissected, and the hair cells counted.


A significant loss of outer hair cells was exhibited in both noise-exposed groups; however, although there was no significant difference between these two groups, the noise-exposed diabetic animals had significant loss in more turns than did the noise-exposed control animals. The diabetic animals were not statistically different from the control animals.


These results suggest that insulin-dependent diabetes mellitus may increase the hair-cell loss caused by noise overstimulation.

Full Text

Duke Authors

Cited Authors

  • Raynor, EM; Carrasco, VN; Prazma, J; Pillsbury, HC

Published Date

  • April 1995

Published In

Volume / Issue

  • 121 / 4

Start / End Page

  • 452 - 456

PubMed ID

  • 7702821

Electronic International Standard Serial Number (EISSN)

  • 1538-361X

International Standard Serial Number (ISSN)

  • 0886-4470

Digital Object Identifier (DOI)

  • 10.1001/archotol.1995.01890040074012


  • eng