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Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer.

Publication ,  Journal Article
Grieco, CA; Simon, CJ; Mayo-Smith, WW; DiPetrillo, TA; Ready, NE; Dupuy, DE
Published in: J Vasc Interv Radiol
July 2006

PURPOSE: To evaluate the clinical outcomes in patients with early-stage non-small-cell lung cancer (NSCLC) after combined treatment with thermal ablation and radiation therapy (RT). MATERIALS AND METHODS: Forty-one patients with inoperable stage I/II NSCLC tumors underwent thermal ablation and RT at our institution between 1998 and 2005. Thirty-seven radiofrequency (RF) ablation procedures and four microwave ablation procedures were performed. Ablations were followed by standard-fraction external-beam RT within 90 days (n = 27) or postprocedural brachytherapy (n = 14). Survival and local recurrence were the primary endpoints evaluated by Kaplan-Meier analysis. RESULTS: The median follow-up was 19.5 months. The overall survival rates were 97.6% at 6 months, 86.8% at 1 year, 70.4% at 2 years, and 57.1% at 3 years. Patients with tumors smaller than 3 cm (n = 17) had an average survival time of 44.4 +/- 5.4 months (SE). Patients with tumors 3 cm or larger (n = 24) had an average survival time of 34.6 +/- 7.0 months (P = .08). Local recurrence occurred in 11.8% of tumors smaller than 3 cm after an average of 45.6 +/- 4.1 months and in 33.3% of the larger tumors after an average of 34.0 +/- 7.8 months (P = .03). Outcomes in the brachytherapy and RT groups did not differ significantly. Nine of 15 pneumothoraces required chest tube drainage (22.0%). CONCLUSIONS: Thermal ablation followed by RT for inoperable stage I/II NSCLC has a relatively low rate of complications that are easily managed. Combined therapy may result in an improved survival compared with either modality alone.

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Published In

J Vasc Interv Radiol

DOI

ISSN

1051-0443

Publication Date

July 2006

Volume

17

Issue

7

Start / End Page

1117 / 1124

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Radiotherapy Dosage
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Middle Aged
  • Microwaves
 

Citation

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MLA
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Grieco, C. A., Simon, C. J., Mayo-Smith, W. W., DiPetrillo, T. A., Ready, N. E., & Dupuy, D. E. (2006). Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiol, 17(7), 1117–1124. https://doi.org/10.1097/01.RVI.0000228373.58498.6E
Grieco, C Alexander, Caroline J. Simon, William W. Mayo-Smith, Thomas A. DiPetrillo, Neal E. Ready, and Damian E. Dupuy. “Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer.J Vasc Interv Radiol 17, no. 7 (July 2006): 1117–24. https://doi.org/10.1097/01.RVI.0000228373.58498.6E.
Grieco CA, Simon CJ, Mayo-Smith WW, DiPetrillo TA, Ready NE, Dupuy DE. Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiol. 2006 Jul;17(7):1117–24.
Grieco, C. Alexander, et al. “Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer.J Vasc Interv Radiol, vol. 17, no. 7, July 2006, pp. 1117–24. Pubmed, doi:10.1097/01.RVI.0000228373.58498.6E.
Grieco CA, Simon CJ, Mayo-Smith WW, DiPetrillo TA, Ready NE, Dupuy DE. Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiol. 2006 Jul;17(7):1117–1124.
Journal cover image

Published In

J Vasc Interv Radiol

DOI

ISSN

1051-0443

Publication Date

July 2006

Volume

17

Issue

7

Start / End Page

1117 / 1124

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Radiotherapy Dosage
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Middle Aged
  • Microwaves