Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.


Journal Article

Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macro-phage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer-deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity.

Full Text

Cited Authors

  • Cohen, PL; Caricchio, R; Abraham, V; Camenisch, TD; Jennette, JC; Roubey, RAS; Earp, HS; Matsushima, G; Reap, EA

Published Date

  • July 1, 2002

Published In

Volume / Issue

  • 196 / 1

Start / End Page

  • 135 - 140

PubMed ID

  • 12093878

Pubmed Central ID

  • 12093878

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20012094


  • eng

Conference Location

  • United States