The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.

Published

Journal Article (Review)

B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.

Full Text

Cited Authors

  • Eisenberg, RA; Sobel, ES; Reap, EA; Halpern, MD; Cohen, PL

Published Date

  • February 1994

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 49 - 54

PubMed ID

  • 8167307

Pubmed Central ID

  • 8167307

Electronic International Standard Serial Number (EISSN)

  • 1096-3618

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1006/smim.1994.1008

Language

  • eng