A cyclic-AMP-gated conductance in cochlear hair cells.


Journal Article

The patch clamp technique was used to record cAMP-dependent currents of the guinea pig cochlear hair cell plasma membrane. Data obtained indicate that the channels passing this current are moderately selective for monovalent cations and are effectively blocked by L-cis-diltiazem and reversibly blocked by 1 mM Mg2+ or Ca2+. The single-channel unit conductance estimated in the absence of divalent cations is about 16 pS. The results demonstrate that cyclic nucleotide-dependent channels of cochlear hair cells are virtually identical to the photoreceptor and olfactory ones.

Full Text

Cited Authors

  • Kolesnikov, SS; Rebrik, TI; Zhainazarov, AB; Tavartkiladze, GA; Kalamkarov, GR

Published Date

  • September 1, 1991

Published In

Volume / Issue

  • 290 / 1-2

Start / End Page

  • 167 - 170

PubMed ID

  • 1717315

Pubmed Central ID

  • 1717315

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(91)81251-3


  • eng