Comparisons of predicted genetic modules: identification of co-expressed genes through module gene flow.

Published

Journal Article

A question of fundamental importance is the definition and identification of modules from microarray experiments. A wide variety of techniques have been used to gain insight into the elucidation of such modules. One problem, however, is the inability to directly compare results between the different data sets produced due to the inherent parameterizations of their approaches. We first aim to provide a mechanism by which different approaches to module finding can be directly compared. Moreover, the same approach can be used to internally compare the modules predicted by the same technique, but at different parameterizations. We apply this approach to analyze the flow of genes through modules at different module thresholds of the Barkai Signature method, thereby further resolving the modules into sets of co-expressed genes.

Full Text

Duke Authors

Cited Authors

  • Shakhnovich, BE; Reddy, TE; Galinsky, K; Mellor, J; Delisi, C

Published Date

  • 2004

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 221 - 228

PubMed ID

  • 15712124

Pubmed Central ID

  • 15712124

International Standard Serial Number (ISSN)

  • 0919-9454

Language

  • eng

Conference Location

  • Japan